Vitamin D and brain health: an observational and Mendelian randomization study
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open access
Keywords:
25-hydroxyvitamin D
vitamin D
Mendelian randomization
dementia
stroke
magnetic resonance imaging
UK Biobank
prospective cohort study
brain volume
Abbreviations:
FLAIR
fluid-attenuated inversion recovery
GRS
genetic risk score
GWAS
genome-wide association study
LACE
localized average causal effect
MR
Mendelian randomization
MR-PRESSO
Mendelian randomization pleiotropy residual sum and outlier
PIF
potential impact fraction
RCT
randomized controlled trial
SNP
single-nucleotide polymorphism
SUNLIGHT
Study of Underlying Genetic Determinants of Vitamin D and Highly Related Traits
TE
time of echo
TR
time of repetition
25(OH)D
25-hydroxyvitamin D.
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Supported by the National Health and Medical Research Council under grants GNT1157281 and GNT1123603.
Supplemental Tables 1–9, Supplemental Figures 1–8, and Supplemental Text S1–S6 are available from the “Supplementary data” link in the online posting of the article at https://academic.oup.com/ajcn/.
Copyright © 2022 American Society for Nutrition. Published by Elsevier Inc. All rights reserved.