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Antismoking agents do not contribute synergistically to semaglutide's ability to reduce alcohol intake in rats.
Aranäs C, Blid Sköldheden S, Jerlhag E. Aranäs C, et al. Among authors: jerlhag e. Front Pharmacol. 2023 Aug 31;14:1180512. doi: 10.3389/fphar.2023.1180512. eCollection 2023. Front Pharmacol. 2023. PMID: 37719854 Free PMC article.
Preclinical studies have identified glucagon-like peptide-1 receptor (GLP-1R) agonists, and the antismoking agents varenicline and bupropion as tentative agents for treatment of alcohol use disorder (AUD). ...Successfully, this approach has been …
Preclinical studies have identified glucagon-like peptide-1 receptor (GLP-1R) agonists, and the antismoking agen …
The glucagon-like peptide-1 (GLP-1) analogue semaglutide reduces alcohol drinking and modulates central GABA neurotransmission.
Chuong V, Farokhnia M, Khom S, Pince CL, Elvig SK, Vlkolinsky R, Marchette RC, Koob GF, Roberto M, Vendruscolo LF, Leggio L. Chuong V, et al. Among authors: leggio l. JCI Insight. 2023 Jun 22;8(12):e170671. doi: 10.1172/jci.insight.170671. JCI Insight. 2023. PMID: 37192005 Free PMC article.
Growing evidence indicates that the glucagon-like peptide-1 (GLP-1) system is involved in the neurobiology of addictive behaviors, and GLP-1 analogues may be used for the treatment of alcohol use disorder (AUD). ...Semaglutide also reduced binge …
Growing evidence indicates that the glucagon-like peptide-1 (GLP-1) system is involved in the neurobiology of ad …
Long-Acting Glucagon-Like Peptide-1 Receptor Agonists Suppress Voluntary Alcohol Intake in Male Wistar Rats.
Marty VN, Farokhnia M, Munier JJ, Mulpuri Y, Leggio L, Spigelman I. Marty VN, et al. Among authors: leggio l. Front Neurosci. 2020 Dec 23;14:599646. doi: 10.3389/fnins.2020.599646. eCollection 2020. Front Neurosci. 2020. PMID: 33424537 Free PMC article.
Despite high prevalence and societal burden, available approved medications to treat AUD are limited in number and efficacy, highlighting a critical need for more and novel pharmacotherapies. Glucagon-like peptide-1 (GLP-1) is a gut hormone and neurope …
Despite high prevalence and societal burden, available approved medications to treat AUD are limited in number and efficacy, highlighting a …
Activation of glucagon-like peptide-1 receptors and skilled reach foraging.
Vestlund J, Bergquist F, Licheri V, Adermark L, Jerlhag E. Vestlund J, et al. Among authors: jerlhag e. Addict Biol. 2021 May;26(3):e12953. doi: 10.1111/adb.12953. Epub 2020 Aug 8. Addict Biol. 2021. PMID: 32770792 Free PMC article.
Glucagon-like peptide-1 receptor (GLP-1R) agonists, such as exendin-4 (Ex4), liraglutide and dulaglutide, regulate glucose homeostasis and are thus used to treat diabetes type II. ...In rats without prior Montoya experience, dulaglutide but not …
Glucagon-like peptide-1 receptor (GLP-1R) agonists, such as exendin-4 (Ex4), liraglutide and dulaglutide, regula …
Long-term treatment with a glucagon-like peptide-1 receptor agonist reduces ethanol intake in male and female rats.
Vallöf D, Kalafateli AL, Jerlhag E. Vallöf D, et al. Among authors: jerlhag e. Transl Psychiatry. 2020 Jul 16;10(1):238. doi: 10.1038/s41398-020-00923-1. Transl Psychiatry. 2020. PMID: 32678077 Free PMC article.
Preclinical studies have shown that acute administration of glucagon-like peptide-1 receptor (GLP-1R) agonists inhibits various ethanol-related behaviours, indicating this system as a potential target for AUD. ...We found that 9 or 5 weeks of on …
Preclinical studies have shown that acute administration of glucagon-like peptide-1 receptor (GLP-1R) agonists i …
Glucagon-like peptide-1 receptors and sexual behaviors in male mice.
Vestlund J, Jerlhag E. Vestlund J, et al. Among authors: jerlhag e. Psychoneuroendocrinology. 2020 Jul;117:104687. doi: 10.1016/j.psyneuen.2020.104687. Epub 2020 Apr 24. Psychoneuroendocrinology. 2020. PMID: 32388229 Free article.
The gut-brain peptide glucagon-like peptide-1 (GLP-1) reduces reward from palatable food and drugs of abuse. ...In addition, these mice displayed higher corticosterone, but not testosterone, levels in plasma. ...
The gut-brain peptide glucagon-like peptide-1 (GLP-1) reduces reward from palatable food and drugs of abuse. ... …
Alcohol-mediated behaviours and the gut-brain axis; with focus on glucagon-like peptide-1.
Jerlhag E. Jerlhag E. Brain Res. 2020 Jan 15;1727:146562. doi: 10.1016/j.brainres.2019.146562. Epub 2019 Nov 21. Brain Res. 2020. PMID: 31759971 Free article. Review.
Gut-brain peptides, such as glucagon-like peptide-1 (GLP-1), are well known for their ability to regulate food intake and appetite. ...These pharmacotherapies, including exenatide/exendin-4(Ex4) and liraglutide, have also been tested in various animal …
Gut-brain peptides, such as glucagon-like peptide-1 (GLP-1), are well known for their ability to regulate food i …
Glucagon-like peptide-1 receptors within the nucleus of the solitary tract regulate alcohol-mediated behaviors in rodents.
Vallöf D, Vestlund J, Jerlhag E. Vallöf D, et al. Among authors: jerlhag e. Neuropharmacology. 2019 May 1;149:124-132. doi: 10.1016/j.neuropharm.2019.02.020. Epub 2019 Feb 14. Neuropharmacology. 2019. PMID: 30772374 Free article.
The ability of glucagon-like peptide-1 (GLP-1) to reduce food intake involves activation of GLP-1 receptors (GLP-1R) in the nucleus of the solitary tract (NTS). ...In addition, NTS-Ex4 dose-dependently decreases alcohol intake in rats con …
The ability of glucagon-like peptide-1 (GLP-1) to reduce food intake involves activation of GLP-1 receptors (GLP …
Brain region specific glucagon-like peptide-1 receptors regulate alcohol-induced behaviors in rodents.
Vallöf D, Kalafateli AL, Jerlhag E. Vallöf D, et al. Among authors: jerlhag e. Psychoneuroendocrinology. 2019 May;103:284-295. doi: 10.1016/j.psyneuen.2019.02.006. Epub 2019 Feb 8. Psychoneuroendocrinology. 2019. PMID: 30771711 Free article.
Glucagon-like peptide 1 (GLP-1), an incretin hormone that reduces food intake, was recently established as a novel regulator of alcohol-mediated behaviors. ...We therefore evaluated the effects of bilateral infusion of the GLP-1R agonist exendin …
Glucagon-like peptide 1 (GLP-1), an incretin hormone that reduces food intake, was recently established as a nov …
The glucagon-like peptide 1 receptor agonist Exendin-4 decreases relapse-like drinking in socially housed mice.
Thomsen M, Dencker D, Wörtwein G, Weikop P, Egecioglu E, Jerlhag E, Fink-Jensen A, Molander A. Thomsen M, et al. Among authors: jerlhag e. Pharmacol Biochem Behav. 2017 Sep;160:14-20. doi: 10.1016/j.pbb.2017.07.014. Epub 2017 Aug 1. Pharmacol Biochem Behav. 2017. PMID: 28778739
Glucagon-like peptide-1 (GLP-1) is a gut peptide that regulates food intake and glucose metabolism. ...Here, we assessed the effect of daily treatment with the GLP-1 receptor agonist Exendin-4 in an assay of relapse-like drinking in socially housed …
Glucagon-like peptide-1 (GLP-1) is a gut peptide that regulates food intake and glucose metabolism. ...Here, we …
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