About My Research
Dr. Benjamin Bleier’s research focuses on the role of sinonasal mucosal barrier function in the pathogenesis of chronic rhinosinusitis. Using a combination of immunohistochemical and air-liquid interface primary epithelial culture techniques, his laboratory is working to determine how transmembrane epithelial proteins, such as the ATP-binding cassette (ABC) transporter P-glycoprotein functions to promote the elaboration of Th1 and Th2 skewed cytokines in the setting of chronic inflammatory disease states.
An additional synergistic interest is studying mucosal permeability and epithelial responses to a variety of topical therapeutics and drug eluting polymers. Using both in vitro and animal models, Dr. Bleier is working to develop methods to bypass the blood-brain barrier using advanced endoscopic surgical techniques. He also studies the ability to couple these procedures with biocompatible materials to enhance the treatment of neurodegenerative disorders and local sinonasal disease.
If you wish to contribute to Dr. Benjamin Bleier's research, please contact Dana Grider.
- RNA therapies for CNS diseases. Adv Drug Deliv Rev. 2024 Mar 16; 208:115283.
- Endoscopic endonasal approach for olfactory groove meningioma resection: Strategies and outcomes in a retrospective case series. J Clin Neurosci. 2024 Apr; 122:93-102.
- Mild repetitive TBI reduces brain-derived neurotrophic factor (BDNF) in the substantia nigra and hippocampus: A preclinical model for testing BDNF-targeted therapeutics. Exp Neurol. 2024 Apr; 374:114696.
- International Consensus Statement on Allergy and Rhinology: Sinonasal Tumors. Int Forum Allergy Rhinol. 2024 Feb; 14(2):149-608.
- Five-year EuroQol 5-Dimension Outcomes After Endoscopic Sinus Surgery. Laryngoscope. 2023 Dec 21.
- Comparison of mucus and serum biomarker sampling in chronic rhinosinusitis with nasal polyps. Int Forum Allergy Rhinol. 2023 Nov 22.
- Acoustic resonance therapy is safe and effective for the treatment of nasal congestion in rhinitis: A randomized sham-controlled trial. Int Forum Allergy Rhinol. 2023 Oct 09.
- Nanotechnology-enabled topical delivery of therapeutics in chronic rhinosinusitis. Nanomedicine (Lond). 2023 Aug; 18(20):1399-1415.
- Endonasal Endoscopic Approach to Orbital Tumors. Int Ophthalmol Clin. 2023 Jul 01; 63(3):249-262.
- Olfactory cleft mucus eosinophil-derived neurotoxin better reflects olfactory loss than blood eosinophil counts in patients with chronic rhinosinusitis. Int Forum Allergy Rhinol. 2023 Dec; 13(12):2144-2155.
- The Impact of Gender on Long-Term Quality of Life After Sinus Surgery for Chronic Rhinosinusitis. Laryngoscope. 2023 12; 133(12):3319-3326.
- Effect of postoperative systemic prednisolone on short-term and long-term outcomes in chronic rhinosinusitis with nasal polyps: A multi-centered randomized clinical trial. Front Immunol. 2023; 14:1075066.
- Orbital resection by intranasal technique (ORBIT): A new classification system for reporting endoscopically resectable primary benign orbital tumors. Int Forum Allergy Rhinol. 2023 10; 13(10):1852-1863.
- Topical Administration of Verapamil in Poly(ethylene glycol)-Modified Liposomes for Enhanced Sinonasal Tissue Residence in Chronic Rhinosinusitis: Ex Vivo and In Vivo Evaluations. Mol Pharm. 2023 03 06; 20(3):1729-1736.
- Aerosol Generation During Nasal Airway Instrumentation. Otolaryngol Head Neck Surg. 2023 03; 168(3):506-513.
- Cold exposure impairs extracellular vesicle swarm-mediated nasal antiviral immunity. J Allergy Clin Immunol. 2023 02; 151(2):509-525.e8.
- CNS Delivery of Nucleic Acid Therapeutics: Beyond the Blood-Brain Barrier and Towards Specific Cellular Targeting. Pharm Res. 2023 Jan; 40(1):77-105.
- Reply. J Allergy Clin Immunol. 2023 01; 151(1):288.
- Nucleic acid therapies for CNS diseases: Pathophysiology, targets, barriers, and delivery strategies. J Control Release. 2022 Dec; 352:121-145.
- Role of 3D Printing in the Development of Biodegradable Implants for Central Nervous System Drug Delivery. Mol Pharm. 2022 Dec 05; 19(12):4411-4427.
- Cystatin SN is a potent upstream initiator of epithelial-derived type 2 inflammation in chronic rhinosinusitis. J Allergy Clin Immunol. 2022 10; 150(4):872-881.
- Defining the Health Utility Value of Medical Management of Chronic Rhinosinusitis: A Prospective Pilot Study. OTO Open. 2022 Apr-Jun; 6(2):2473974X221092381.
- Endoscopic surgery for intraconal orbital tumors. HNO. 2022 May; 70(5):345-351.
- Traumatic brain injury and the development of parkinsonism: Understanding pathophysiology, animal models, and therapeutic targets. Biomed Pharmacother. 2022 May; 149:112812.
- Mechanisms and pathogenesis of chronic rhinosinusitis. J Allergy Clin Immunol. 2022 05; 149(5):1491-1503.
- Phase I safety and tolerability study of topical verapamil HCl in chronic rhinosinusitis with nasal polyps. Int Forum Allergy Rhinol. 2022 08; 12(8):1071-1074.
- Nasal delivery of nanotherapeutics for CNS diseases: challenges and opportunities. Nanomedicine (Lond). 2021 12; 16(30):2651-2655.
- Reflecting on the COVID-19 Surgical Literature Surge: A Scoping Review of Pandemic Otolaryngology Publications. Otolaryngol Head Neck Surg. 2022 07; 167(1):65-72.
- Acute and Chronic Sinusitis. Med Clin North Am. 2021 Sep; 105(5):859-870.
- Osmotic core-shell polymeric implant for sustained BDNF AntagoNAT delivery in CNS using minimally invasive nasal depot (MIND) approach. Biomaterials. 2021 09; 276:120989.
- In vivo analysis of endocanalicular light pipe transillumination in endoscopic dacryocystorhinostomy: Anatomic considerations and cautions for the transitioning. Orbit. 2022 Aug; 41(4):447-451.
- Association of Sinonasal Inflammation With Functional Brain Connectivity. JAMA Otolaryngol Head Neck Surg. 2021 06 01; 147(6):534-543.
- Endonasal CNS Delivery System for Blood-Brain Barrier Impermeant Therapeutic Oligonucleotides Using Heterotopic Mucosal Engrafting. Front Pharmacol. 2021; 12:660841.
- P-glycoprotein inhibition with verapamil overcomes mometasone resistance in Chronic Sinusitis with Nasal Polyps. Rhinology. 2021 Apr 01; 59(2):205-211.
- The Endoscopic Transnasal Approach to Orbital Tumors: A Review. Semin Ophthalmol. 2021 May 19; 36(4):232-240.
- Clinical Implications of Psychophysical Olfactory Testing: Assessment, Diagnosis, and Treatment Outcome. Front Neurosci. 2021; 15:646956.
- International consensus statement on allergy and rhinology: rhinosinusitis 2021. Int Forum Allergy Rhinol. 2021 03; 11(3):213-739.
- Airborne aerosol olfactory deposition contributes to anosmia in COVID-19. PLoS One. 2021; 16(2):e0244127.
- IMPROVING BARRIER DRAPES FOR THE MITIGATION OF AEROSOL AND PARTICULATE SPREAD DURING MASTOIDECTOMY. Otol Neurotol. 2021 02 01; 42(2):347-349.
- Minimally Invasive Nasal Depot (MIND) technique for direct BDNF AntagoNAT delivery to the brain. J Control Release. 2021 03 10; 331:176-186.
- Valuing diversity, equity, and inclusion. Int Forum Allergy Rhinol. 2021 01; 11(1):5.
- Exclusively endoscopic endonasal resection of benign orbital tumors: a systematic review and meta-analysis. Int Forum Allergy Rhinol. 2021 05; 11(5):924-934.
- COVID-19 Vaccines May Not Prevent Nasal SARS-CoV-2 Infection and Asymptomatic Transmission. Otolaryngol Head Neck Surg. 2021 02; 164(2):305-307.
- Aerosol-scavenging isolation barrier mitigates exposure risk during endonasal procedures in coronavirus-2019. Int Forum Allergy Rhinol. 2021 06; 11(6):1015-1018.
- AHNS endocrine surgery section consensus statement on nasopharyngolaryngoscopy and clinic reopening during COVID-19: How to get back to optimal safe care. Head Neck. 2021 02; 43(2):733-738.
- Prophylactic and therapeutic topical povidone-iodine in coronavirus disease 2019 (COVID-19): What is the evidence? Int Forum Allergy Rhinol. 2020 12; 10(12):1271-1273.
- Radioanatomic Characteristics of the Posteromedial Intraconal Space: Implications for Endoscopic Resection of Orbital Lesions. AJNR Am J Neuroradiol. 2020 12; 41(12):2327-2332.
- Endoscopic endonasal resection of orbital schwannoma assisted with small-incision medial orbitotomy: case series and surgical technique. Orbit. 2021 Dec; 40(6):536-542.
- Demonstration and Mitigation of Aerosol and Particle Dispersion During Mastoidectomy Relevant to the COVID-19 Era. Otol Neurotol. 2020 10; 41(9):1230-1239.
- Definition and characteristics of acute exacerbation in adult patients with chronic rhinosinusitis: a systematic review. J Otolaryngol Head Neck Surg. 2020 Aug 18; 49(1):62.
- Preprocedural COVID-19 screening: Do rhinologic patients carry a unique risk burden for false-negative results? Int Forum Allergy Rhinol. 2020 10; 10(10):1186-1188.
- Suction mitigation of airborne particulate generated during sinonasal drilling and cautery. Int Forum Allergy Rhinol. 2020 10; 10(10):1136-1140.
- Aerosol Dispersion During Mastoidectomy and Custom Mitigation Strategies for Otologic Surgery in the COVID-19 Era. Otolaryngol Head Neck Surg. 2021 01; 164(1):67-73.
- Reply to: Endonasal drilling may be employed safely in the COVID-19 era. Int Forum Allergy Rhinol. 2020 09; 10(9):1120.
- Guidance for contemporary use of biologics in management of chronic rhinosinusitis with nasal polyps: discussion from a National Institutes of Health-sponsored workshop. Int Forum Allergy Rhinol. 2020 09; 10(9):1037-1042.
- Topical glucocorticoid treatment for chronic rhinosinusitis in the biologic era. Int Forum Allergy Rhinol. 2020 08; 10(8):933-935.
- Biologic therapies versus surgical management for aspirin-exacerbated respiratory disease: A review of preliminary data, efficacy, and cost. World J Otorhinolaryngol Head Neck Surg. 2020 Dec; 6(4):230-234.
- Response to Aerosol or droplet: critical definitions in the COVID-19 era. Int Forum Allergy Rhinol. 2020 08; 10(8):970.
- Endoscopic management of lateral sphenoid cerebrospinal fluid leaks: Identifying a radiographic parameter for surgical planning. Laryngoscope Investig Otolaryngol. 2020 Jun; 5(3):375-380.
- Airborne Aerosol Generation During Endonasal Procedures in the Era of COVID-19: Risks and Recommendations. Otolaryngol Head Neck Surg. 2020 09; 163(3):465-470.
- Endonasal instrumentation and aerosolization risk in the era of COVID-19: simulation, literature review, and proposed mitigation strategies. Int Forum Allergy Rhinol. 2020 Jul; 10(7):798-805.
- Lynch vs transcaruncular approach: optimizing access to the lateral frontal sinus. Int Forum Allergy Rhinol. 2020 08; 10(8):991-995.
- Demonstration and mitigation of aerosol and particle dispersion during mastoidectomy relevant to the COVID-19 era. Otol Neurotol. 2020 May 08.
- Superior turbinate eosinophilia predicts olfactory decline in patients with chronic rhinosinusitis. Ann Allergy Asthma Immunol. 2020 09; 125(3):304-310.e1.
- Microbiotyping the Sinonasal Microbiome. Front Cell Infect Microbiol. 2020; 10:137.
- The international sinonasal microbiome study: A multicentre, multinational characterization of sinonasal bacterial ecology. Allergy. 2020 08; 75(8):2037-2049.
- Clinical Research Needs for the Management of Chronic Rhinosinusitis with Nasal Polyps in the New Era of Biologics: A National Institute of Allergy and Infectious Diseases Workshop. J Allergy Clin Immunol Pract. 2020 05; 8(5):1532-1549.e1.
- Delivery of neurotrophic factors in the treatment of age-related chronic neurodegenerative diseases. Expert Opin Drug Deliv. 2020 03; 17(3):323-340.
- Unexpected effects of systemic steroids on the CRSwNP proteome: is protein upregulation more important than inhibition? Int Forum Allergy Rhinol. 2020 03; 10(3):334-342.
- Use of off-label steroid irrigations in chronic rhinosinusitis: a survey of the American Rhinologic Society. Int Forum Allergy Rhinol. 2020 04; 10(4):575-576.
- Significant polyomic and functional upregulation of the PAPP-A/IGFBP-4/5/IGF-1 axis in chronic rhinosinusitis with nasal polyps. Int Forum Allergy Rhinol. 2020 04; 10(4):546-555.
- Sample collection for laboratory-based study of the nasal airway and sinuses: a research compendium. Int Forum Allergy Rhinol. 2020 03; 10(3):303-313.
- Current Understanding of the Acute Exacerbation of Chronic Rhinosinusitis. Front Cell Infect Microbiol. 2019; 9:415.
- Endoscopic endonasal intraconal orbit surgery. World J Otorhinolaryngol Head Neck Surg. 2020 Jun; 6(2):100-105.
- Development of a Modular Cadaveric Endoscopic Orbital Surgery Model. Am J Rhinol Allergy. 2020 Mar; 34(2):183-188.
- Lightening in a bottle: comparison of ultraviolet light to traditional sterilization in saline irrigations bottles. Int Forum Allergy Rhinol. 2020 01; 10(1):53-58.
- Escalation in mucus cystatin 2, pappalysin-A, and periostin levels over time predict need for recurrent surgery in chronic rhinosinusitis with nasal polyps. Int Forum Allergy Rhinol. 2019 10; 9(10):1212-1219.
- Discriminant analysis followed by unsupervised cluster analysis including exosomal cystatins predict presence of chronic rhinosinusitis, phenotype, and disease severity. Int Forum Allergy Rhinol. 2019 09; 9(9):1069-1076.
- ICAR: endoscopic skull-base surgery. Int Forum Allergy Rhinol. 2019 07; 9(S3):S145-S365.
- Future topical medications in chronic rhinosinusitis. Int Forum Allergy Rhinol. 2019 05; 9(S1):S32-S46.
- Improvement in nasal obstruction and quality of life after septorhinoplasty and turbinate surgery. Laryngoscope. 2019 07; 129(7):1554-1560.
- Development of the international orbital Cavernous Hemangioma Exclusively Endonasal Resection (CHEER) staging system. Int Forum Allergy Rhinol. 2019 07; 9(7):804-812.
- Tissue and Exosomal Serine Protease Inhibitors Are Significantly Overexpressed in Chronic Rhinosinusitis With Nasal Polyps. Am J Rhinol Allergy. 2019 Jul; 33(4):359-368.
- Translating transcription: proteomics in chronic rhinosinusitis with nasal polyps reveals significant discordance with messenger RNA expression. Int Forum Allergy Rhinol. 2019 07; 9(7):776-786.
- Selective photobiomodulation for emotion regulation: model-based dosimetry study. Neurophotonics. 2019 Jan; 6(1):015004.
- Does bilateral inferior turbinate reduction affect long-term quality-of-life outcomes in patients undergoing endoscopic sinus surgery? Int Forum Allergy Rhinol. 2019 06; 9(6):601-606.
- Osteitis is associated with dysregulated pro-osteoblastic activity in patients with nasal polyps. Laryngoscope. 2019 03; 129(3):E102-E109.
- Oxidative Post-translational Modifications Accelerate Proteolytic Degradation of Calprotectin. J Am Chem Soc. 2018 12 19; 140(50):17444-17455.
- Direct CNS delivery of proteins using thermosensitive liposome-in-gel carrier by heterotopic mucosal engrafting. PLoS One. 2018; 13(12):e0208122.
- Noninvasive exosomal proteomic biosignatures, including cystatin SN, peroxiredoxin-5, and glycoprotein VI, accurately predict chronic rhinosinusitis with nasal polyps. Int Forum Allergy Rhinol. 2019 02; 9(2):177-186.
- Exosome swarms eliminate airway pathogens and provide passive epithelial immunoprotection through nitric oxide. J Allergy Clin Immunol. 2019 04; 143(4):1525-1535.e1.
- Postoperative Opioid Use in Sinonasal Surgery. Otolaryngol Head Neck Surg. 2019 03; 160(3):402-408.
- SNOT-22 score patterns strongly negatively predict chronic rhinosinusitis in patients with headache. Int Forum Allergy Rhinol. 2019 01; 9(1):9-15.
- A Shift in the Orbit: Immediate Endoscopic Reconstruction After Transnasal Orbital Tumors Resection: Response. J Craniofac Surg. 2018 09; 29(6):1674-1675.
- Highly multiplexed proteomic analysis reveals significant tissue and exosomal coagulation pathway derangement in chronic rhinosinusitis with nasal polyps. Int Forum Allergy Rhinol. 2018 12; 8(12):1438-1444.
- Temporary olfactory improvement in chronic rhinosinusitis with nasal polyps after treatment. Eur Arch Otorhinolaryngol. 2018 Sep; 275(9):2193-2202.
- TREM-1 Neutrophil Activation Pathway Is Suppressed in Eosinophilic Nasal Polyps. Am J Rhinol Allergy. 2018 Sep; 32(5):359-368.
- Axonal Guidance Signaling Pathway Is Suppressed in Human Nasal Polyps. Am J Rhinol Allergy. 2018 Jul; 32(4):208-216.
- Morphometric Analysis of the Orbital Process of the Palatine Bone and its Relationship to Endoscopic Orbital Apex Surgery. Ophthalmic Plast Reconstr Surg. 2018 May/Jun; 34(3):254-257.
- A golden age in skull base and rhinology research. Int Forum Allergy Rhinol. 2018 05; 8(5):561-562.
- Revision eDCR using a superior pedicled mucosal flap. Orbit. 2019 Feb; 38(1):1-6.
- Emerging Role of Proteases in the Pathogenesis of Chronic Rhinosinusitis with Nasal Polyps. Front Cell Infect Microbiol. 2017; 7:538.
- The sinonasal microbiota, neural signaling, and depression in chronic rhinosinusitis. Int Forum Allergy Rhinol. 2018 03; 8(3):394-405.
- Osteologic analysis of ethnic differences in supernumerary ethmoidal foramina: implications for endoscopic sinus and orbit surgery. Int Forum Allergy Rhinol. 2018 05; 8(5):655-658.
- Expanding the limits of endoscopic intraorbital tumor resection using 3-dimensional reconstruction. Braz J Otorhinolaryngol. 2019 Mar - Apr; 85(2):157-161.
- Prospective transfrontal sheep model of skull-base reconstruction using vascularized mucosa. Int Forum Allergy Rhinol. 2018 05; 8(5):614-619.
- Case of the month. Int Forum Allergy Rhinol. 2017 12; 7(12):1119-1120.
- Exosome function in aerodigestive mucosa. Nanomedicine. 2018 02; 14(2):269-277.
- Clinical Phenotypes of Nasal Polyps and Comorbid Asthma Based on Cluster Analysis of Disease History. J Allergy Clin Immunol Pract. 2018 Jul - Aug; 6(4):1297-1305.e1.
- Trends in sinusitis research: a systematic review of extramural funding. Int Forum Allergy Rhinol. 2017 11; 7(11):1104-1107.
- Long-term impact of endoscopic orbital decompression on sinonasal-specific quality of life. Laryngoscope. 2018 04; 128(4):785-788.
- Compartmental Endoscopic Surgical Anatomy of the Inferior Intraconal Orbital Space. J Neurol Surg B Skull Base. 2018 Apr; 79(2):189-192.
- A Retrospective Review of Orbital Decompression for Thyroid Orbitopathy with Endoscopic Preservation of the Inferomedial Orbital Bone Strut. Ophthalmic Plast Reconstr Surg. 2017 Sep/Oct; 33(5):334-339.
- Endoscopic DCR using bipedicled interlacing mucosal flaps. Laryngoscope. 2018 04; 128(4):794-797.
- Does the Timing of Middle Turbinate Resection Influence Quality-of-Life Outcomes for Patients with Chronic Rhinosinusitis? Otolaryngol Head Neck Surg. 2017 11; 157(5):874-879.
- Exosomes mediate interepithelial transfer of functional P-glycoprotein in chronic rhinosinusitis with nasal polyps. Laryngoscope. 2017 09; 127(9):E295-E300.
- Double-blind placebo-controlled randomized clinical trial of verapamil for chronic rhinosinusitis with nasal polyps. J Allergy Clin Immunol. 2017 07; 140(1):271-273.
- Anosmia: Differential diagnosis, evaluation, and management. Am J Rhinol Allergy. 2017 Jan 01; 31(1):3-7.
- Antibiotics in eosinophilic chronic rhinosinusitis: Rethinking maximal antimicrobial medical therapy. Laryngoscope. 2017 04; 127(4):794-796.
- Microarray analysis of the genes associated with osteitis in chronic rhinosinusitis. Laryngoscope. 2017 03; 127(3):E85-E90.
- Pseudomonas Aeruginosa: A Masquerader in Sino-Orbital Infections. Ophthalmic Plast Reconstr Surg. 2016 Sep-Oct; 32(5):374-7.
- Impact of endoscopic dacryocystorhinostomy on sinonasal quality of life. Am J Rhinol Allergy. 2016 Sep; 30(5):189-91.
- Secreted P-glycoprotein is a noninvasive biomarker of chronic rhinosinusitis. Laryngoscope. 2017 01; 127(1):E1-E4.
- General antibiotic exposure is associated with increased risk of developing chronic rhinosinusitis. Laryngoscope. 2017 02; 127(2):296-302.
- Influence of P-Glycoprotein Function on Chronic Rhinosinusitis/Nasal Polyps Pathophysiology. Adv Otorhinolaryngol. 2016; 79:38-47.
- Benefit of Preoperative Oral Steroids during Sinus Surgery when Utilizing Concentrated Topical Epinephrine. ORL J Otorhinolaryngol Relat Spec. 2016; 78(4):216-22.
- Response to: The RACE national database for recurrent acute rhinosinusitis may need a relook. Int Forum Allergy Rhinol. 2016 10; 6(10):1100.
- Intact soluble P-glycoprotein is secreted by sinonasal epithelial cells. Am J Rhinol Allergy. 2016 Jul; 30(4):246-9.
- Surgical Management of Severe Epistaxis. Otolaryngol Clin North Am. 2016 Jun; 49(3):627-37.
- Comparative techniques of medial rectus muscle retraction for endoscopic exposure of the medial intraconal space. Am J Rhinol Allergy. 2016 May; 30(3):226-9.
- An Algorithm for Surgical Approach to the Anterior Skull Base. J Neurol Surg B Skull Base. 2016 Aug; 77(4):364-70.
- Heterotopic Mucosal Grafting Enables the Delivery of Therapeutic Neuropeptides Across the Blood Brain Barrier. Neurosurgery. 2016 Mar; 78(3):448-57; discussion 457.
- Use of a retinal sponge for silicone tube fixation after bicanalicular lacrimal intubation or dacryocystorhinostomy. Orbit. 2016; 35(2):97.
- Endoscopic management of orbital tumors. Curr Opin Otolaryngol Head Neck Surg. 2016 Feb; 24(1):57-62.
- Endoscopic endonasal orbital cavernous hemangioma resection: global experience in techniques and outcomes. Int Forum Allergy Rhinol. 2016 Feb; 6(2):156-61.
- P-glycoprotein regulates Staphylococcus aureus enterotoxin B-stimulated interleukin-5 and thymic stromal lymphopoietin secretion in organotypic mucosal explants. Int Forum Allergy Rhinol. 2016 Feb; 6(2):169-77.
- Bypassing the blood-brian barrier using established skull base reconstruction techniques. World J Otorhinolaryngol Head Neck Surg. 2015 Sep; 1(1):11-16.
- Purely endoscopic trans-nasal management of orbital intraconal cavernous haemangiomas: a systematic review of the literature. Eur Arch Otorhinolaryngol. 2016 Sep; 273(9):2319-22.
- Safety and efficacy of concentrated topical epinephrine use in endoscopic endonasal surgery. Int Forum Allergy Rhinol. 2015 Dec; 5(12):1118-23.
- Invasive fungal disease of the sinus and orbit: a comparison between mucormycosis and Aspergillus. Br J Ophthalmol. 2016 Feb; 100(2):184-8.
- Immediate and Delayed Complications Following Endoscopic Skull Base Surgery. J Neurol Surg B Skull Base. 2015 Sep; 76(5):390-6.
- Volumetric analysis of chronic maxillary atelectasis. Am J Rhinol Allergy. 2015 May-Jun; 29(3):166-9.
- Centrifugal frontal sinus dissection technique: addressing anterior and posterior frontoethmoidal air cells. Int Forum Allergy Rhinol. 2015 Aug; 5(8):761-3.
- Itraconazole and clarithromycin inhibit P-glycoprotein activity in primary human sinonasal epithelial cells. Int Forum Allergy Rhinol. 2015 Jun; 5(6):477-80.
- A simple, single stage technique to harvest optimal ethmoid bone grafts for caudal septal deflections. Int Forum Allergy Rhinol. 2015 Jul; 5(7):622-5.
- The blood-brain barrier and nasal drug delivery to the central nervous system. Am J Rhinol Allergy. 2015 Mar-Apr; 29(2):124-7.
- Oral steroids and intraoperative bleeding during endoscopic sinus surgery. B-ENT. 2015; 11(2):123-8.
- Verapamil modulates interleukin-5 and interleukin-6 secretion in organotypic human sinonasal polyp explants. Int Forum Allergy Rhinol. 2015 Jan; 5(1):10-3.
- P-glycoprotein inhibition promotes prednisone retention in human sinonasal polyp explants. Int Forum Allergy Rhinol. 2014 Sep; 4(9):734-8.
- Heterotopic mucosal engrafting procedure for direct drug delivery to the brain in mice. J Vis Exp. 2014 Jul 16; (89).
- The nasoseptal flap for reconstruction of the medial and inferior orbit. Int Forum Allergy Rhinol. 2014 Sep; 4(9):763-6.
- Endoscopic bimanual approach to an intraconal cavernous hemangioma of the orbital apex with vascularized flap reconstruction. Ophthalmic Plast Reconstr Surg. 2014 Jul-Aug; 30(4):e104-6.
- Editorial: Blending medical and surgical therapies to optimize patient outcomes in chronic rhinosinusitis and allergic rhinitis. Am J Rhinol Allergy. 2014 Jul-Aug; 28(4):279-80.
- Compartmental endoscopic surgical anatomy of the medial intraconal orbital space. Int Forum Allergy Rhinol. 2014 Jul; 4(7):587-91.
- P-glycoprotein promotes epithelial T helper 2-associated cytokine secretion in chronic sinusitis with nasal polyps. Int Forum Allergy Rhinol. 2014 Jun; 4(6):488-94.
- Osteitis is associated with P-glycoprotein overexpression in patients with chronic sinusitis without nasal polyps. Am J Rhinol Allergy. 2014 Mar-Apr; 28(2):99-102.
- Endoscopic orbital floor decompression with preservation of the inferomedial strut. Int Forum Allergy Rhinol. 2014 Jan; 4(1):82-4.
- Outcomes analysis in epistaxis management: development of a therapeutic algorithm. Otolaryngol Head Neck Surg. 2013 Sep; 149(3):390-8.
- P-glycoprotein is a marker of tissue eosinophilia and radiographic inflammation in chronic rhinosinusitis without nasal polyps. Int Forum Allergy Rhinol. 2013 Aug; 3(8):684-7.
- Permeabilization of the blood-brain barrier via mucosal engrafting: implications for drug delivery to the brain. PLoS One. 2013; 8(4):e61694.
- P-glycoprotein functions as an immunomodulator in healthy human primary nasal epithelial cells. Int Forum Allergy Rhinol. 2013 Jun; 3(6):433-8.
- Evaluation of a polysaccharide gel for laser-assisted skull base repair. Am J Rhinol Allergy. 2013 Mar-Apr; 27(2):148-50.
- Anteriorly based pedicled flaps for skull base reconstruction. Adv Otorhinolaryngol. 2013; 74:64-70.
- Novel techniques and the future of skull base reconstruction. Adv Otorhinolaryngol. 2013; 74:174-83.
- The accessory posterolateral nerve: an immunohistological analysis. Am J Rhinol Allergy. 2012 Jul-Aug; 26(4):271-3.
- Dose quantification of topical drug delivery to the paranasal sinuses by fluorescein luminosity calculation. Int Forum Allergy Rhinol. 2012 Jul-Aug; 2(4):316-20.
- Regional expression of epithelial MDR1/P-glycoprotein in chronic rhinosinusitis with and without nasal polyposis. Int Forum Allergy Rhinol. 2012 Mar-Apr; 2(2):122-5.
- Primary human sinonasal epithelial cell culture model for topical drug delivery in patients with chronic rhinosinusitis with nasal polyposis. J Pharm Pharmacol. 2012 Mar; 64(3):449-56.
- Laser facial nerve welding in a rabbit model. Arch Facial Plast Surg. 2012 Jan-Feb; 14(1):52-8.
- Temporospatial quantification of fluorescein-labeled sinonasal irrigation delivery. Int Forum Allergy Rhinol. 2011 Sep-Oct; 1(5):361-5.
- The bipedicled anterior septal flap: a radioanatomic and cadaveric study. Laryngoscope. 2011 Jul; 121(7):1367-71.
- Mucocele rate after endoscopic skull base reconstruction using vascularized pedicled flaps. Am J Rhinol Allergy. 2011 May-Jun; 25(3):186-7.
- Increased presence of dendritic cells and dendritic cell chemokines in the sinus mucosa of chronic rhinosinusitis with nasal polyps and allergic fungal rhinosinusitis. Int Forum Allergy Rhinol. 2011 Jul-Aug; 1(4):296-302.
- Vitamin D3 correlates inversely with systemic dendritic cell numbers and bone erosion in chronic rhinosinusitis with nasal polyps and allergic fungal rhinosinusitis. Clin Exp Immunol. 2011 Jun; 164(3):312-20.
- Endoscopic anatomy of the postganglionic pterygopalatine innervation of the posterolateral nasal mucosa. Int Forum Allergy Rhinol. 2011 Mar-Apr; 1(2):113-7.
- Preliminary study on the stability of beta-2 transferrin in extracorporeal cerebrospinal fluid. Otolaryngol Head Neck Surg. 2011 Jan; 144(1):101-3.
- Factors predicting endoscopic exposure of Zenker's diverticulum. Ann Otol Rhinol Laryngol. 2010 Nov; 119(11):736-41.
- Evolving materials and techniques for endoscopic sinus surgery. Otolaryngol Clin North Am. 2010 Jun; 43(3):653-72, xi.
- Novel topical therapeutics. Otolaryngol Clin North Am. 2010 Jun; 43(3):539-49, viii-ix.
- Prevention and management of medial rectus injury. Otolaryngol Clin North Am. 2010 Aug; 43(4):801-7.
- Endonasal laser tissue welding: first human experience. Am J Rhinol Allergy. 2010 May-Jun; 24(3):244-6.
- Laser tissue welding in lung and tracheobronchial repair: an animal model. Chest. 2010 Aug; 138(2):345-9.
- Antibiotic eluting chitosan glycerophosphate implant in the setting of acute bacterial sinusitis: a rabbit model. Am J Rhinol Allergy. 2010 Mar-Apr; 24(2):129-32.
- Fluid residuals and drug exposure in nasal irrigation. Otolaryngol Head Neck Surg. 2009 Dec; 141(6):757-61.
- Cranial-base repair using endoscopic laser welding. Otolaryngol Clin North Am. 2009 Oct; 42(5):901-6, xi.
- Septoplasty complications: avoidance and management. Otolaryngol Clin North Am. 2009 Jun; 42(3):463-81.
- Current management of juvenile nasopharyngeal angiofibroma: a tertiary center experience 1999-2007. Am J Rhinol Allergy. 2009 May-Jun; 23(3):328-30.
- Chitosan glycerophosphate-based semirigid dexamethasone eluting biodegradable stent. Am J Rhinol Allergy. 2009 Jan-Feb; 23(1):76-9.
- Effects of an LL-37-derived antimicrobial peptide in an animal model of biofilm Pseudomonas sinusitis. Am J Rhinol Allergy. 2009 Jan-Feb; 23(1):46-51.
- Otolaryngologic Clinics of North America. Cranial Base Repair Using Endoscopic Laser Welding (ELW). 2009; 5(42):901-906.
- Otolaryngologic Clinics of North America. Septoplasty Complications: Avoidance and Management. 2009; 3(42):463-481.
- Laser-welded endoscopic endoluminal repair of iatrogenic esophageal perforation: an animal model. Otolaryngol Head Neck Surg. 2008 Nov; 139(5):713-7.
- In vivo laser tissue welding in the rabbit maxillary sinus. Am J Rhinol. 2008 Nov-Dec; 22(6):625-8.
- Diffuse intranasal papillomatosis and its association with human papillomavirus. Arch Otolaryngol Head Neck Surg. 2008 Jul; 134(7):778-80.
- Rhinosinusitis: A Guide to Diagnosis and Management. Complications of Sinusitis. 2008.
- Revision Sinus Surgery. Recurrent Mucoceles. 2008.
- Dysphagia after chemoradiation: analysis by modified barium swallow. Ann Otol Rhinol Laryngol. 2007 Nov; 116(11):837-41.
- Laser-assisted cerebrospinal fluid leak repair: an animal model to test feasibility. Otolaryngol Head Neck Surg. 2007 Nov; 137(5):810-4.
- Rhinologic and Sleep Apnea Surgical Techniques. Paranasal Sinus Mucoceles. 2007.
- Image guided transoral approach to the pterygopalatine fossa. Laryngoscope. 2006 Oct; 116(10):1927-9.
- Technetium Tc 99m sestamibi sensitivity in oxyphil cell-dominant parathyroid adenomas. Arch Otolaryngol Head Neck Surg. 2006 Jul; 132(7):779-82.
- Operative Techniques in Otolaryngology Head and Neck Surgery. State of the Art Cerebrospinal Fluid Leak and Encephalocele Repair. 2006; 1(17):49-57.
- Eccrine porocarcinoma of the nose: case report and review of world literature. Arch Otolaryngol Head Neck Surg. 2006 Feb; 132(2):215-8.
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Proteomic Approach to the Diagnosis and Treatment of Chronic Rhinosinusitis
The Bleier Lab has discovered the presence of P-glycoprotein (P-gp) upregulation in patients with chronic rhinosinusitis with nasal polyps (CRSwNP). This overexpression directly leads to the selective epithelial hypersecretion of Th2 polarizing cytokines which are characteristic of CRSwNP. Dr. Bleier recently completed a double-blind, placebo-controlled, randomized clinical trial demonstrating that inhibition of P-gp is effective in controlling both subjective and objective symptoms of nasal polyps. His lab has further shown that both P-gp and other proteins are released into nasal mucus via exosomes. These mucus derived exosomes or “rhinosomes” be non-invasively detected to generate a novel quantitative biosignature of CRS using a proteomic array. This biosignature can then be used to classify patients by disease endotype and guide therapy by predicting the specific inflammatory pathways which may be up or downregulated.
Endoscopic Orbital Surgery
Along with collaborators from the division of Ophthalmic Plastic Surgery, Dr. Bleier, Co-Director of the Center for Thyroid Eye Disease and Orbital Surgery, is developing an array of minimally invasive surgical approaches to the orbit including new methods for orbital decompression and dacryocystorhinostomy. His team has pioneered an endoscopic method to remove orbital tumors entirely through the nose while avoiding any external incisions.
Trans-Nasal Drug Delivery to the Central Nervous System
The Bleier Lab has developed the first and only method to permanently bypass the blood-brain barrier using nasal mucosal grafts. Dr. Bleier and his collaborators have used this method to deliver high molecular weight proteins and nucleic acids to the brain which would otherwise be restricted by the blood-brain barrier. This approach has been recognized by the Michael J. Fox Foundation, Boston Magazine, Harvard Medicine Magazine, and Scientist Magazine. Current projects are directed at using this delivery pathway to develop new treatments for neurodegenerative disorders including Alzheimer’s and Parkinson's disease.