Ai Peng Tan

Ai Peng Tan

Singapore
88 followers 68 connections

Activity

Experience

Education

  • European Diploma in Neuroradiology (EDiNR)

Publications

  • CAR T-cell therapy-related neurotoxicity in paediatric acute lymphocytic leukaemia

    Pediatric Blood & Cancer

  • CAR-T cell Therapy Related Neurotoxicity in Pediatric Acute Lymphoblastic Leukaemia (ALL): Spectrum of Imaging Findings

    Pediatr Neurol. 2020

  • Tan AP. CAR-T cell Therapy Related Neurotoxicity in Pediatric Acute Lymphoblastic Leukaemia (ALL): Spectrum of Imaging Findings. Pediatr Neurol. 2020; doi:10.1016/j.pediatrneurol.2020.06.014

    Pediatr Neurol. 2020

  • Ong SJ, Renfrew I, AnilSIR HELMET (Safety In Radiology HEalthcare Localised Metrological EnviromenT): a low-cost negative-pressure isolation barrier for shielding MRI frontline workers from COVID-19 exposure.

    Clinical Radiology

  • Gaunt T, Mankad K, Calder A, Tan AP, Talenti G, Watson TA, et al. Abnormalities of the craniovertebral junction in the paediatric population: a novel biomechanical approach. Clin Radiol. 2018;73: 839–854. doi:10.1016/j.crad.2018.05.020

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  • Kee CK, Ngam PI, Tan AP. An Unusual Cause of Stroke-Like Symptoms in an Elderly Patient. Ann Acad Med Singap. 2019;48: 306–309.

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  • Lim YT, Mankad K, Kinali M, Tan AP. Neuroimaging spectrum of inherited neurotransmitter disorders. Neuropediatrics. 2020;51: 6–21. doi:10.1055/s-0039-1698422

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  • Lin JB, Sng AA, Wang FS, Tan AP, Han VX. Acute hemichorea in a young type 1 diabetic. Int J Neurosci. 2019; 1–3. doi:10.1080/00207454.2019.1702540

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  • Mankad K, Biswas A, Espagnet MCR, Dixon L, Reddy N, Tan AP, et al. Venous pathologies in paediatric neuroradiology: from foetal to adolescent life. Neuroradiology. 2019; doi:10.1007/s00234-019-02294-x

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  • Mankad K, Talenti G, Tan AP, Gonçalves FG, Robles C, Kan EYL, et al. Neurometabolic disorders of the newborn. Top Magn Reson Imaging. 2018;27: 179–196. doi:10.1097/RMR.0000000000000176

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  • Ngam PI, Hussain SS, Tan AP. Congenital pial AVF along the falx cerebri with complete agenesis of the corpus callosum and bilateral parasagittal pachygyria-polymicrogyria secondary to chronic ischemia. Childs Nerv Syst. 2019;35: 569–574. doi:10.1007/

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  • Siakallis L, Tan AP, Chorbachi R, Mankad K. A unique case of CHARGE syndrome with craniosynostosis. Childs Nerv Syst. 2019;35: 11–13. doi:10.1007/s00381-018-4005-5

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  • Sng WJ, Kapur J, Sundar G, Lian WQD, Tan AP. Utilization of contrast-enhanced ultrasound in the evaluation of craniofacial osseous lesions: A case report. Clin Imaging. 2019;60: 5–9. doi:10.1016/j.clinimag.2019.10.018

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  • Staglianò S, D’Arco F, Tan AP, Jeelani O, Morana G, Mankad K. Haemostatic material (Surgicel®) mimicking residual tumour: magnetic resonance imaging findings in operated pediatric neuro-oncology cases. Quant Imaging Med Surg. 2018;8: 971–978. doi:10.

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  • Tan AP, Chong WK, Mankad K. Comprehensive genotype-phenotype correlation in lissencephaly. Quant Imaging Med Surg. 2018;8: 673–693. doi:10.21037/qims.2018.08.08

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  • Tan AP, Chong WK. A child with Apert syndrome and Sturge-Weber syndrome: could fibronectin or the RAS/MAPK signaling pathway be the connection? Childs Nerv Syst. 2018;34: 1247–1250. doi:10.1007/s00381-018-3758-1

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  • Tan AP, Chua BS, Lim KB, Taneja M. Unusual clinical presentation of nutcracker phenomenon. Ann Acad Med Singap. 2017;46: 470–471.

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  • Tan AP, Gonçalves FG, Almehdar A, Soares BP. Clinical and neuroimaging spectrum of peroxisomal disorders. Top Magn Reson Imaging. 2018;27: 241–257. doi:10.1097/RMR.0000000000000172

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  • Tan AP, Jacques TS, Mankad K, James G, Jeelani O, Slater O, et al. Melanotic neuroectodermal tumour of infancy: A case report and differential diagnosis. Neuroradiol J. 2017;31: 1971400917741770. doi:10.1177/1971400917741770

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  • Tan AP, Lim YT. “Restricted Diffusion” within the Splenium of the Corpus Callosum: A Potential Pitfall in Young Infants on 3T Imaging and Marker of Normal Myelin Maturation. Neuropediatrics. 2019;50: 146–151. doi:10.1055/s-0039-1679899

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  • Tan AP, Lim YT. Response to letter to the editor: diffusion of the corpus callosum in young infants. Neuropediatrics. 2019; doi:10.1055/s-0039-1694987

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  • Tan AP, Mankad K, Gonçalves FG, Talenti G, Alexia E. Macrocephaly: solving the diagnostic dilemma. Top Magn Reson Imaging. 2018;27: 197–217. doi:10.1097/RMR.0000000000000170

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  • Tan AP, Mankad K. A unique case of lissencephaly with Crouzon syndrome heterozygous for FGFR2 mutation. Childs Nerv Syst. 2017; doi:10.1007/s00381-017-3646-0

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  • Tan AP, Mankad K. Adams Oliver syndrome with cerebellar cortical dysplasia. Childs Nerv Syst. 2018;34: 1109–1110. doi:10.1007/s00381-018-3810-1

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  • Tan AP, Mankad K. Apert syndrome: magnetic resonance imaging (MRI) of associated intracranial anomalies. Childs Nerv Syst. 2018;34: 205–216. doi:10.1007/s00381-017-3670-0

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  • Tan AP, Mankad K. Intraventricular glioblastoma multiforme in a child with L2-hydroxyglutaric aciduria. World Neurosurg. 2017;110: 288–290. doi:10.1016/j.wneu.2017.11.106

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  • Tan AP, Priego G. Thanatophoric dysplasia type 1 with tectal plate dysplasia and aqueductal stenosis. Childs Nerv Syst. 2019;35: 1059–1061. doi:10.1007/s00381-018-04035-6

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  • Tan AP, Robles C, Mankad K. Cerebellar atrophy with T2/FLAIR hyperintense cerebellar cortex: a new imaging phenotype of combined complex II/III deficiency. Childs Nerv Syst. 2018; doi:10.1007/s00381-018-3762-5

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  • Tan AP, Sahil C, Robinson R, Siddiqui A, Wraige E, Chandler C, et al. Neuroimaging in Juvenile Alexander Disease: Tumour-like Brainstem Lesions. Ann Acad Med Singap. 2018;47: 191–193.

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  • Tan AP, Schonstedt V, Roberts M, Barnacle A, Jacques T, Rayyah YA, et al. Lower lid mass in a neonate. Ann Acad Med Singap. 2019;48: 69–71.

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  • Tan AP, Svrckova P, Cowan F, Chong WK, Mankad K. Intracranial hemorrhage in neonates: A review of etiologies, patterns and predicted clinical outcomes. Eur J Paediatr Neurol. 2018;22: 690–717. doi:10.1016/j.ejpn.2018.04.008

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  • Tan AP, Tan CL, Pang YH, Kei PL. Anaplastic Oligodendroglioma with Transdural Extension. World Neurosurg. 2019;130: 10–12. doi:10.1016/j.wneu.2019.06.146

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  • Tan AP, Taneja M, Hui F. Posterior fossa dural arteriovenous fistula presenting clinically as a carotid-cavernous fistula treated by a direct access cavernous sinus approach. J Neurointerv Surg. 2014;6: e49. doi:10.1136/neurintsurg-2013-010939.rep

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  • Tan AP, Taneja M, Seah BH, Leong HN, Venketasubramanian N. Acute free-floating carotid artery thrombus causing stroke in a young patient: unique etiology and management using endovascular approach. J Stroke Cerebrovasc Dis. 2014;23: e437-9. doi:10.10

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  • Tan AP, Wong YLJ, Lin BJ, Yong HRC, Mankad K. Clinico-radiological approach to cerebral hemiatrophy. Childs Nerv Syst. 2018;34: 1–14. doi:10.1007/s00381-018-3934-3

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  • Tan AP. Degenerated retained product of conception misdiagnosed as invasive trophoblastic disease. Med J Malaysia. 2015;70: 100–101.

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  • Tan AP. Down syndrome: multimodality imaging of associated congenital anomalies and acquired diseases. Med J Malaysia. 2013;68: 482–489.

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  • Tan AP. Febrile Infection-Related Epilepsy Syndrome (FIRES) with Multifocal Subcortical Infarcts, A New Imaging Phenotype. Neuropediatrics. 2018;49: 347–352. doi:10.1055/s-0038-1661418

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  • Tan AP. MRI Protocol for Craniosynostosis: Replacing Ionizing Radiation-Based CT. AJR Am J Roentgenol. 2019;213: 1374–1380. doi:10.2214/AJR.19.21746

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  • Tan AP. Post-operative Unilateral Internal Cerebral Vein (ICV) Thrombosis with Venous Watershed Infarcts: A Case Report with Review of the Literature. World Neurosurg. 2020; doi:10.1016/j.wneu.2020.03.008

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  • Tan AP. Primary normocephalic pancraniosynostosis detected incidentally after an accidental head injury: a case report and review of the literature. Childs Nerv Syst. 2018;34: 1–5. doi:10.1007/s00381-018-3768-z

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  • Tan LY, Tan AP. A rare case of paediatric meningioma masquerading as intra-axial lesion. Med J Malaysia. 2018;73: 439–440.

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  • Vincent Tiong TY, Sundar G, Young SM, Makmur A, Clement Yong HR, Jocelyn Wong YL, et al. A novel method of CT exophthalmometry in patients with thyroid eye disease. Asia Pac J Ophthalmol (Phila). 2020; doi:10.1097/01.APO.0000617908.29733.84

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  • Wen J, Tan AP, Yong HRC, Wong YLJ. Delayed radiation necrosis and evolution of its imaging features over time: an illustrative case report. J Oncol Pract. 2018;14: 754–756. doi:10.1200/JOP.18.00488

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  • Wu P, Tan AP. Small Head with Big Vessels. Ann Acad Med Singap. 2019;48: 165–168.

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Projects

  • “Black Bone” Imaging Replacing Ionising-Based Imaging Modalities For Pediatric Craniofacial Disorders (Primary Investigator)

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  • A Novel Method of CT Exophthalmometry in Patients with Thyroid Eye Disease (Primary Investigator)

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  • A phase 1/2 , open-label, safety, tolerability, pharmacokinetics and anti-tumor activity study of repotrectinib in pediatric and young adult subjects with advanced or metastatic malignancies harbouring ALK, ROS1, or NTRK1-3 alterations (Co-Investigator)

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  • A Phase 2b/3 Prospective, Randomized, Double Blind, Sham-Controlled Trial of VTS-270 (2-hydroxypropyl-β-cyclodextrin) in Subjects with Neurologic Manifestations of Niemann-Pick Type C1 (NPC1) Disease (Co-Investigator)

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  • ALaCART: Acute Leukaemia and CAR-T - Chimeric-Antigen Receptor (CAR) T-Cell Therapy Using Multiple CARs and Cell Marker Profiling in High Risk and Relapsed/ Refractory B-Lineage Acute Lymphoblastic Leukaemia (Co-Investigator)

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  • BRAIN AGE study: Determination of Myelination Milestone Using a Machine-Learning Framework (Primary Investigator)

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  • Comparison of imaging characteristics of glioneuronal tumours in a paediatric cohort and correlation with histopathology (Primary Investigator)

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  • Growing Up Towards Healthy Outcomes (GUSTO) (Co-Investigator) (A*STAR: Industry Alignment Fund (Pre-positioning) (IAF-PP)

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  • Mapping Antenatal Maternal Stress (MAMS) (Co-Investigator) (A*STAR: Industry Alignment Fund (Pre-positioning) (IAF-PP)

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  • Maternal Vector-borne Infection (MVI) study. A prospective longituidinal cohort study to assess the impact of Zika and other mosquito-borne viral infections on pregnancy outcome (Co-Investigator) (NUHS Ad-hoc Strategic Grant Call)

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  • Multi-Omics approach in Glioma Prognostication (Co-Investigator)

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  • Radiogenomic Correlation of the newly proposed Molecular Characterization of Glioneuronal Tumours of the brain. (Co-Investigator)

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  • Relative “Restricted Diffusion” within the splenium of the corpus callosum of young infants on 3T Imaging. (Primary Investigator)

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  • Singapore PREconception Study of long-Term maternal and child Outcomes (S-PRESTO)

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  • TROG Cancer Research (A randomized phase II trial of Osimertinib with or without stereotactic radiosurgery for EGFR mutated Non-Small Cell Lung Cancer with brain metastases) (Co-Investigator) (NMRC Individual Research Grant (IRG)

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  • Use of Arterial Spin Labelling (ASL) MR perfusion imaging and Montreal Cognitive Assessment (MoCA) test to improve diagnostic yield of Transient Ischemic Attack (TIA) (Co-Investigator) (NLAM Clinician Scientist Unit "Pitch for Funds")

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Honors & Awards

  • Anugerah Pelajaran DiRaja (Pingat Jaya Cemerlang)

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  • 'Dr. Balwant Singh's' Gold Medal, 2005/2006

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  • 'Lokman Saim' Gold Medal, 2005/2006

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  • Academic Medicine Development Award (2016-2017) to subspecialise in Pediatric Neuroradiology at the Great Ormond Street Hospital for Children NHS Foundation Trust

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  • Dean’s Prize for Best Academic Performance– 2005/2006

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  • Tunku Abdul Rahman Award – Best Undergraduate (Public University) – 2007

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Organizations

  • Fellow of the Royal College of Radiologists

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  • Member of Asia-Oceania Society of Paediatric Radiology (AOSPR)

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  • Member of European Society of Neuroradiology (ESNR)

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  • Member of European Society of Radiology (ESR)

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  • Member of Singapore Medical Association (SMA)

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  • Member of Singapore Radiological Society (SRS)

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  • Member of the Singapore Medical Council (SMC)

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