Monday, May 20, 2024
More
    Home Blog

    U.S. and Europe Move Closer to Using Russian Assets to Help Ukraine

    0

    The United States and Europe are coalescing around a plan to use interest earned on frozen Russian central bank assets to provide Ukraine with a loan to be used for military and economic assistance, potentially providing the country with a multibillion-dollar lifeline as Russia’s war effort intensifies.

    Treasury Secretary Janet L. Yellen said in an interview on Sunday that several options for using $300 billion in immobilized Russian assets remained on the table. But she said the most promising idea was for Group of 7 nations to issue a loan to Ukraine that would be backed by profits and interest income that is being earned on Russian assets held in Europe.

    Finance ministers from the Group of 7 will be meeting in Italy later this week in hopes of finalizing a plan that they can deliver to heads of state ahead of the group’s leaders meeting next month. The urgency to find a way to deliver more financial support to Ukraine has been mounting as the country’s efforts to fend off Russia have shown signs of faltering.

    “I think we see considerable interest among all of our partners in a loan structure that would bring forward the stream of windfall profits,” Ms. Yellen said during her flight to Germany, where she is holding meetings ahead of the Group of 7 summit. “It would generate a significant up-front amount that would help meet needs we anticipate Ukraine is going to have both militarily and through reconstruction.”

    For months, Western allies have been debating how far to go in using the Russian central bank assets. The United States believes that it would be legal under international law to confiscate the money and give it to Ukraine, but several European countries, including France and Germany, have been wary about the lawfulness of such a move and the precedent that it would set.

    Although the United States recently passed legislation that would give the Biden administration the authority to seize and confiscate Russian assets, the desire to act in unison with Europe has largely sidelined that idea.

    This month, European Union nations agreed in principle that they would be willing to use 90 percent of the profits to buy arms for Ukraine through the European Peace Facility, an E.U. structure to finance military aid and its own military missions. The remaining 10 percent would go to reconstruction and nonlethal purchases, to satisfy countries like Ireland, Austria, Cyprus and Malta, which are militarily neutral.

    About 190 billion euros of Russian central bank assets are held by Belgium’s central securities depository, Euroclear. The assets are generating about €3 billion a year of interest that could be transferred to Ukraine.

    However, using the interest as the basis for a loan could provide Ukraine with a much larger amount of money — potentially as much as $50 billion — up front. The method for delivering the money still needs to be worked out. The World Bank or another international institution could serve as an intermediary.

    It also remains unclear how the loan would be repaid if the war ended before the bond matured or if interest rates fell, making the proceeds on the assets insufficient to repay the loan.

    Such details are expected to be debated among the finance ministers when they gather later this week. They hope to be able to provide Ukraine with additional funds this summer.

    Ms. Yellen said that allocating the money to Ukraine was critical for showing Russia that it could not outlast Western support.

    “I think Russia is playing a waiting game and they’ve had the view that the U.S. and our partners are losing the will to support Ukraine over an extended time,” Ms. Yellen said. “Showing that we do have the means of translating earnings on the frozen assets into a stream of support for Ukraine, I think, is an important way to demonstrate that we’re not about to fold — we’re going to be able to help Ukraine.”

    Remarks by Chair Powell at the Georgetown University Law Center commencement ceremony

    0

    Accessible Keys for Video

    [Space Bar] toggles play/pause;

    [Right/Left Arrows] seeks the video forwards and back (5 sec );

    [Up/Down Arrows] increase/decrease volume;

    [M] toggles mute on/off;

    [F] toggles fullscreen on/off (Except IE 11);

    The [Tab] key may be used in combination with the [Enter/Return] key to navigate and activate control buttons, such as caption on/off.

    Thank you, Dean Treanor, for the invitation to speak here today. I am very sorry that circumstances prevent me from joining you in person.

    I will start by acknowledging the parents, spouses, partners, other family members and mentors who are here. Without your support, sacrifice, and encouragement, we would not have so much to celebrate today.

    And to the class of 2024—congratulations on earning your law degree. You are the most selective class in Georgetown history, chosen from 14,000 applicants, and the most well qualified as well. Among you are Fulbright scholars, military veterans, Peace Corps, AmeriCorps and Teach for America alumni, student athletes, accomplished musicians and even a medical doctor. An impressive group. This is also the most diverse class in the 154-year history of the school.

    I am especially proud today to say that there is a lot of Georgetown in my family tree. My father graduated from the College in 1943 before serving in the U.S. Army in World War II. After the war, he received his law degree here and practiced law in Washington, D.C. I am fortunate to have two wonderful daughters; one graduated from the College in 2012; the other is a member of the Class of 2026 at the Law Center.

    It seems like yesterday that I was in your shoes, receiving my degree, looking forward with optimism and excitement, and wondering what lay ahead.

    I cannot help but think fondly of my time here. For many years, friends from law school have gathered annually for a weekend to refresh our ties and laugh about times gone by. These gatherings are referred to as “Big Chill,” a reference to a 1983 movie that revolved around a mid-life reunion of college friends. I made lifelong friendships here that I keep to this day, and I hope it will be the same for you.

    Along with all the hard work, I also remember the fun. A favorite tradition was to attend Saturday midnight showings of The Rocky Horror Picture Show at the Key Theater on Wisconsin Avenue in Georgetown.

    Now, if you have led a culturally deprived life and are tragically unfamiliar with the movie, it is a raucous musical starring a young Tim Curry. Everyone in the theater would sing along, shout out the lines, and throw popcorn at the screen; many would dress up like the characters. Now, I didn’t dress up—sorry to disappoint you—but no party was complete until all of us danced “The Time Warp” to the movie’s famous song.

    As it happens, I still remember the steps, and I had intended to demonstrate the Time Warp for you, but that will not be possible today.

    Instead, I will offer a few thoughts that I might have benefited from hearing when I was sitting in your chairs a mere 45 years ago.

    Embracing Change

    The years since my graduation have brought waves of fundamental change to the workplace and to society at large, much of it driven by technology. Imagine a world with no internet, no email or texting, no personal computers or cell phones, no social media. Some of you parents are no doubt thinking: I would be fine with that world!

    The pace of change will likely continue to be very fast. Be alert to the ways your working life may change. Think about how you can be prepared for those changes and to turn them to your advantage, and to society’s advantage. The practice of law has been transformed over the years; if you do choose the path of a practicing lawyer, I would think about what practicing law could look like in 10 or 20 years.

    In a world that will continue to evolve quickly and in unexpected ways, you will need to be agile. Embracing change and taking risks can be an important part of your development as a professional and as a person. Your formal education may end today, but you are not done learning. Many of the important things you will need to know can only be learned through experience. And experience can be a hard but irreplaceable teacher.

    As an example, near the end of my second year here, it was time to select the next editor in chief of the Georgetown Law Journal. I thought that there were plenty of colleagues who were better qualified, but who simply did not want the job. So, with much trepidation, I put my name in. I was secretly, but utterly, terrified that I might be chosen. And amazingly enough, I was. What now?

    It turned out that, as I feared, I was not well prepared for that responsibility. I had to keep people interested and motivated enough to work on the Journal when many things competed for their attention. I had to have a plan for the organization and not just for myself. I had to do this while exhibiting confidence that I did not feel. My main memory of that time is thinking, “This is harder and far different from what I had expected!”

    What I now know is that almost no one is ready for their first leadership roles. When you step into a leadership role, it is very common to doubt yourself. If I could tell my younger self something, it would be to believe in yourself and put yourself in situations in which you will be seriously challenged to do new things. Assume that you will make mistakes. Learn from those mistakes; do not dwell excessively upon them in regret. You will fall down. Get up. Repeat cycle.

    The more you do that, the more you will learn and the faster you will develop as a person and as a leader. Know also that, in my experience, there is no single model of a successful leader. Each of you has it in you to lead successfully.

    No One Path

    One of the great things about your legal education is it sets you up for success on a wide variety of potential paths. I left the practice of law a few years after I left this school. But my legal education has benefited me all along the way. Studying law teaches you to think clearly, analyze thoroughly, and understand all sides of an argument. The possibilities that lie ahead of you are extremely broad. You may work for a single law firm for your entire career. Or you may leave the law fairly soon, as I did, and never look back. You will always benefit from what you learned here.

    The fact is, I do keep a copy of the Federal Reserve Act that I consult often.

    Like many of you, I imagine, I knew that I wanted to do public service. As I left law school, I remember thinking about people like George Shultz and Cyrus Vance, prominent figures of the day who had successful private-sector careers and served periodically in government.

    The head of the investment bank in New York where I worked as a young man was Nicholas F. Brady, who had an extraordinary career in investment banking and had served as a U.S. senator from New Jersey as well. I was the most junior of employees, but I wanted to introduce myself and tell him about my own aspirations. But approaching him was daunting. Maybe he would decline to meet with me. Maybe he would think I was not committed to the firm if I told him I was interested in public service.

    I finally summoned the courage to present myself at his office. I told him that I grew up in Washington, had been a federal law clerk and a congressional staffer, and wanted to do public service along the way. I said that if you need someone to staff you on anything you do in Washington, I’m your guy. He said something along the lines of, “Great, thanks.” I then crept back down the stairs to my broom closet of an office wondering whether that was going to matter.

    A few months later, I got a call from his secretary. I can still hear her gravelly voice. “Can you come up and see Mr. Brady?” When I got there, he said, “I need you to help me out with this thing.” This thing was defending an oil company from a hostile takeover attempt by a colorful corporate raider of that era named T. Boone Pickens. I ended up spending months going back and forth from New York to Washington with Nick. A few years later, Nick Brady became the Treasury Secretary. Nick asked me to join him at Treasury, which opened the door for me to higher levels of public service. The point is this: if I had not forced myself to get up from my desk, taken the stairs up to the 15th floor, and presented myself to his office that day, the rest of my life would have been very different, and I would not be standing here today.

    Mustering that little bit of initiative changed my life. A little initiative can make all the difference in anyone’s career.

    Conclusion

    I will conclude by encouraging you to think beyond yourselves. Each of you has the capability to achieve success in any field you choose; it is important that you also consider how to give back and use your gifts to make a difference. Reflect on the motto of this school: “law is but the means; justice is the end.” Many of you have served at law clinics where you stood up for underrepresented individuals and organizations. And many of you will play important roles in the military, at nonprofits, and in governments around the world.

    Each generation has an obligation to move us closer to the ideal, as embodied by the famous image of blindfolded Lady Justice holding the scales. You should count yourselves among the luckiest in all our society to graduate from this institution, to have the support of loved ones through three grueling years, and the health and other good fortune not to get tripped up along the way. Several years ago, one of my predecessors, Ben Bernanke, said, “Those who are the luckiest . . . also have the greatest responsibility to work hard, to contribute to the betterment of the world, and to share their luck with others.” I cannot improve upon that.

    I thank you for having me. Georgetown will always hold a special place in my heart. Thank you again to Dean Treanor and all the faculty, and the hardiest of congratulations to the Class of 2024.

    Helicopter with Iran president Raisi suffers ‘hard landing,’ state TV says

    0

    DUBAI, United Arab Emirates (AP) — A helicopter carrying Iranian President Ebrahim Raisi, the country’s foreign minister and other officials apparently crashed in the mountainous northwest reaches of Iran on Sunday, sparking a massive rescue operation in a fog-shrouded forest as the public was urged to pray.

    The likely crash came as Iran under Raisi and Supreme Leader Ayatollah Ali Khamenei launched an unprecedented drone-and-missile attack on Israel last month and has enriched uranium closer than ever to weapons-grade levels.

    Iran has also faced years of mass protests against its Shiite theocracy over an ailing economy and women’s rights — making the moment that much more sensitive for Tehran and the future of the country as the Israel-Hamas war inflames the wider Middle East.

    Raisi was traveling in Iran’s East Azerbaijan province. State TV said what it called a “hard landing” happened near Jolfa, a city on the border with the nation of Azerbaijan, some 600 kilometers (375 miles) northwest of the Iranian capital, Tehran. Later, state TV put it farther east near the village of Uzi, but details remained contradictory.

    Traveling with Raisi were Iran’s Foreign Minister Hossein Amirabdollahian, the governor of Iran’s East Azerbaijan province and other officials and bodyguards, the state-run IRNA news agency reported. One local government official used the word “crash,” but others referred to either a “hard landing” or an “incident.”

    Neither IRNA nor state TV offered any information on Raisi’s condition in the hours afterward. However, hard-liners urged the public to pray for him. State TV later aired images of the faithful praying at Imam Reza Shrine in the city of Mashhad, one of Shiite Islam’s holiest sites, as well as in Qom and other locations across the country. State television’s main channel aired the prayers nonstop.

    “The esteemed president and company were on their way back aboard some helicopters and one of the helicopters was forced to make a hard landing due to the bad weather and fog,” Interior Minister Ahmad Vahidi said in comments aired on state TV. “Various rescue teams are on their way to the region but because of the poor weather and fogginess it might take time for them to reach the helicopter.”

    IRNA called the area a “forest” and the region is known to be mountainous as well. State TV aired images of SUVs racing through a wooded area and said they were being hampered by poor weather conditions, including heavy rain and wind.

    A rescue helicopter tried to reach the area where authorities believe Raisi’s helicopter was, but it couldn’t land due to heavy mist, emergency services spokesman Babak Yektaparast told IRNA.

    Long after the sun set, Iranian government spokesman Ali Bahadori Jahromi acknowledged that “we are experiencing difficult and complicated conditions” in the search.

    “It is the right of the people and the media to be aware of the latest news about the president’s helicopter accident, but considering the coordinates of the incident site and the weather conditions, there is ‘no’ new news whatsoever until now,” he wrote on the social platform X. “In these moments, patience, prayer and trust in relief groups are the way forward.”

    Khamenei himself also urged the public to pray.

    “We hope that God the Almighty returns the dear president and his colleagues in full health to the arms of the nation,” Khamenei said, drawing an “amen” from the audience he was addressing.

    Raisi, 63, a hard-liner who formerly led the country’s judiciary, is viewed as a protégé of Khamenei and some analysts have suggested he could replace the 85-year-old leader after Khamenei’s death or resignation from the role.

    Raisi had been on the border with Azerbaijan early Sunday to inaugurate a dam with Azerbaijan’s President Ilham Aliyev. The dam is the third one that the two nations built on the Aras River. The visit came despite chilly relations between the two nations, including over a gun attack on Azerbaijan’s Embassy in Tehran in 2023, and Azerbaijan’s diplomatic relations with Israel, which Iran’s Shiite theocracy views as its main enemy in the region.

    Iran flies a variety of helicopters in the country, but international sanctions make it difficult to obtain parts for them. Its military air fleet also largely dates back to before the 1979 Islamic Revolution. IRNA published images it described as Raisi taking off in what resembled a Bell helicopter, with a blue-and-white paint scheme previously seen in published photographs.

    Raisi won Iran’s 2021 presidential election, a vote that saw the lowest turnout in the Islamic Republic’s history. Raisi is sanctioned by the U.S. in part over his involvement in the mass execution of thousands of political prisoners in 1988 at the end of the bloody Iran-Iraq war.

    Under Raisi, Iran now enriches uranium at nearly weapons-grade levels and hampers international inspections. Iran has armed Russia in its war on Ukraine, as well as launched a massive drone-and-missile attack on Israel amid its war against Hamas in the Gaza Strip. It also has continued arming proxy groups in the Mideast, like Yemen’s Houthi rebels and Lebanon’s Hezbollah.

    Meanwhile, mass protests in the country have raged for years. The most recent involved the 2022 death of Mahsa Amini, a woman who had been earlier detained over allegedly not wearing a hijab, or headscarf, to the liking of authorities. The monthslong security crackdown that followed the demonstrations killed more than 500 people and saw over 22,000 detained.

    In March, a United Nations investigative panel found that Iran was responsible for the “physical violence” that led to Amini’s death.

    President Joe Biden was briefed by aides on the Iran crash, but administration officials have not learned much more than what is being reported publicly by Iran state media, said a senior administration official, who was not authorized to comment publicly and spoke on condition of anonymity.

    ___

    Associated Press writers Nasser Karimi in Tehran, Iran, and Aamer Madhani in Washington contributed to this report.

    The Windows PC is about to get GOOD, and you can thank Windows on Arm for that

    0

    On Monday, Microsoft will unveil its vision for a new era of the Windows PC, consisting of new Arm-based silicon from Qualcomm and paired with next-gen AI experiences that will result in new Windows devices that are always aware of what you’re doing, able to translate languages in real time, improve your webcam with artificial lighting and filters, artificially increase gaming performance, and generate text and images on-device.

    This combination of hardware and software is something Microsoft has been working towards since early 2021, after it held an all-hands meeting with leaders across Windows and Surface to discuss just how it was going to respond to Apple Silicon. The company discussed a project called CADMUS, the goals of which were to bring to market a new era of Windows devices that are performant, efficient, and AI capable.

    IF Friends $59M At Global Box Office; Planet Of The Apes Rises To $238M

    Refresh for latest…:  After starting early offshore release on John Krasinski’s IF last weekend, Paramount expanded the imaginary friends film to another 56 international box office markets this session. The overseas frame was worth $20M, bringing the international running cume to $24M. With domestic’s $35M debut, the worldwide total is now $59M.

    Despite some unfriendly critical scores, IF is hearing positive word of mouth which should help playability. 

    The Krasinski directed/written/produced movie saw terrific uplift on Saturday versus Friday in the majority of offshore majors. It opened at No. 1 in the UK with $3.2M including previews. Staggered school holidays are ahead there. Mexico was a No. 2 start with $2.8M; Australia grossed $2M in a No. 1 launch; Germany picked up $905K at No. 4 with Monday a national holiday and school breaks afoot; Spain was a No. 2 start at $850K.

    Other notable openings include Italy ($815K/No. 1), Brazil ($735K/No. 2), Korea ($480K/No. 6), UAE ($300K/No. 3) and Poland ($265K/No. 1).

    France is the top market to date with $5.2M after two frames. Greece and Norway release next week with Japan due on June 14.

    With strong holds overseas, 20th Century Studios/Disney’s Kingdom of the Planet of the Apes added $40.6M from 52 material international box office markets in the sophomore session. The offshore cume is now $136.3M for $237.5M global.

    Looking at the Friday/Saturday/Sunday frame, the international hold is just 35% off last weekend’s opening (excluding China). On a similar basis, KPA showed significantly better staying power than Dawn of the Planet of the Apes (-41%), Rise of the Planet of the Apes (-43%) and War for the Planet of the Apes (-51%).

    Notably sticky markets were Brazil (-21%), UK (-23%), Germany (-26%), Australia (-32%), Italy (-33%), Korea (-33%) and Spain (-36%). This Wes Ball-directed installment is already the highest grossing film of the franchise in Bulgaria, Turkey and Colombia. This frame it remained the top non-local title in all major European and Asian markets. It’s the overall No. 1 still in Latin America. 

    Here are the Top 5 to date: China ($20.4M), France ($13.8M), Mexico ($12M), UK ($10M) and Korea ($5.8M).

    In IMAX, the total is $21.8M global. 

    Columbia Pictures/Alcon Entertainment’s The Garfield Movie keeps purring overseas with another $10.3M from just 27 markets in the third frame and before it releases domestically next weekend. The overseas hold was just -28% and the cume is $49M. There is still 40% of the offshore pawprint ahead including Saudi Arabia, UK, Indonesia, Australia, Poland, France and Japan.

    Universal’s The Fall Guy rolled to another $7.2M from 81 markets including $900K in its China debut. The overseas cume is now $64.6M, in line with The Lost City at the same point in release. Globally the Ryan Gosling/Emily Blunt-starrer has grossed $127.6M to date. 

    The Top 5 markets are: UK ($10.3M), Australia ($7.6M), Germany ($4.3M), France ($4.2M) and Mexico ($4M).

    MISC UPDATED CUMES/NOTABLE
    Tarot (SNY): $5M intl weekend (52 markets); $14.5M intl cume/$30M global
    Challengers (WB): $2.6M intl weekend (61 markets); $35.2M intl cume/$78.7M global
    Kung Fu Panda 4 (UNI): $1.7M intl weekend (82 markets); $340.8M intl cume/$533.4M global
    Abigail (UNI): $1.3M intl weekend (77 markets); $14.2M intl cume/$39.8M global
    Bob Marley: One Love (PAR): $750K intl weekend (Japan only/final market); $81.6M intl cume/$178.5M global
    Back to Black (UNI): $387K intl weekend (41 Universal markets); $6.1M intl cume/$9M global

    Rishi Sunak’s wife Akshata Murty is richer than King Charles; Here’s a look at Sudha Murty’s daughter’s lifestyle and net worth – Lifestyle News

    0

    UK Prime Minister Rishi Sunak and his wife Akshata Murty now possess more personal wealth than King Charles, according to the latest Sunday Times Rich List.

    The Sunday Times Rich List ranks the 1,000 wealthiest individuals and families residing in the United Kingdom by their net worth. This year, the couple’s fortune saw an impressive increase of over £120 million, rising from £529 million in 2023 to £651 million in 2024, surpassing the wealth of King Charles.

    Education

    Murty attended Baldwin Girls’ High School, Bangalore, and in 1998 studied economics and French at Claremont McKenna College in California. She furthered her education by earning a Master of Business Administration (MBA) degree from Stanford University. Later, she started her own fashion company called Akshata Designs and invested in tech companies, making her lots of money.

    Family

    Besides being a big shot in business, Akshata is also a loving wife and mom. Since 2009 she has been married to Rishi Sunak, the current Prime Minister of the United Kingdom and leader of the Conservative Party. They have two daughters – Anoushka and Krishna. She juggles her busy work life with taking care of her family.

    Philanthropies

    Inspired by her mom’s charity work, Sudha Murty, Akshata also gives back to the community. She supports projects that help people who need it, showing her kind heart. She recently has also donated her shares in the childcare company Koru Kids to charity.

    Living the High Life:

    Akshata and her family live in fancy houses in London and go to fancy parties. Murty and Sunak own a portfolio of impressive properties. Their real estate holdings include a luxurious five-bedroom house in Kensington, London, valued at £7 million. Additionally, they have a stunning residence in Santa Monica, California. These properties reflect their affluent lifestyle and keen investment sense.

    In 2010, Akshata Murty launched her fashion label, Akshata Designs. Her brand is known for blending Indian and Western styles, creating unique fusion clothing. She collaborates with artists from remote villages in India, ensuring her designs are deeply rooted in Indian culture. As highlighted in a 2011 Vogue profile, Murty’s clothes serve as “vehicles to discovering Indian culture.”

    Net worth

    Murty’s wealth grew by £122 million last year. Together, their estimated net worth rose from £529 million in 2023 to £651 million, as per the latest list by Sunday Times.

    PGA Championship Round 4 live updates, leaderboard: Who will emerge from the logjam atop the leaderboard?

    0

    It’s been a bit since a major championship produced a truly dramatic finish. It’s gonna take something special for anyone to run away with the 2024 PGA Championship.

    Starting Sunday, 15 players will be within five shots of the lead. Collin Morikawa and Xander Schauffele, at -15, are a shot clear of Sahith Theegala, who stood tough Saturday despite a rough start. Behind them, well, we’ve got a traffic jam.

    Theegala immediately tied both Schauffele and Morikawa with an early birdie on Sunday afternoon, too, with a deep birdie putt. It’s in the early stages of the final round at Valhalla in Louisville, but it’s setting up to be a wild Sunday.

    If you’re looking for how to watch, click here.

    If you’re looking for the leaderboard, click here.

    If you’re looking for tee times, click here.

    And if you’re looking for on-course updates … we’ve got you covered right here …

    Live13 updates

    • DeChambeau now two back of Schauffele

      Bryson DeChambeau hit a fantastic second shot to set up an easy birdie putt on No. 2 to move to 14-under and two shots back of Xander Schauffele.

    • Xander Schauffele birdies No. 1

      Xander Schauffele birdies his first hole to get to 16-under and one shot clear of Collin Morikawa and Sahith Theegala.

      Schauffele’s second shot barely got over the bunker in front of the green but rolled out to give him a decent look for birdie that he converted.

    • Sahith Theegala gets to 15-under with a 55-footer

      Sahith Theegala has joined Xander Schauffele and Collin Morikawa at 15-under with a remarkable 55-foot birdie putt on No. 1.

    • Here we go …

      Everyone is now on the course, including the co-leaders, Collin Morikawa and Xander Schauffele.

      Schauffele’s drive on No. 1 tricked into the right rough; Morikawa found the fairway.

      Up ahead, Bryson DeChambeau had a good look at birdie on No. 1 to get to within a shot of the lead but pulled it. Can’t let those opportunities slip by on a day like today when red numbers are there for the taking.

    • Logjam is jamming up

      With some of those atop the leaderboard now on the course, 17 players are now within five shots of the lead. That includes Justin Thomas (-11), who holed out from the greenside bunker at No. 3.

    • Valhalla’s got snakes

      No need for grounds crew when you got this guy …

    • As the chasers to Xander Schauffele and Collin Morikawa begin their rounds, Lee Hodges makes a move early. He’s now -11 and four shots back of the lead after a birdie on No. 1.

      Scottie Scheffler, meanwhile, is still hitting shots like these even though he’s out of contention for the win following his poor round on Saturday.

    • What score will it take to win?

      With Xander Schauffele and Collin Morikawa at 15-under to start, what score is it going to take to win today? David Duval said on the CBS broadcast that 19-under wins it. With all the red numbers on the board so far today, the guess here is even lower — 20-under.

      That would be 66 from the leaders, and with 63 there for the taking, that brings everyone who is 12-under or better in the mix:

      Schauffele (-15)
      Morikawa (-15)
      Theegala (-14)
      Lowry (-13)
      DeChambeau (-13)
      Hovland (-13)
      Rose (-12)
      MacIntyre (-12)

    • Turns out, Scottie Scheffler is human

      A day after his first over-par round since last August, Scottie Scheffler has gotten off to a hom-hum start to round 4. A bogey at the first, followed by a missed six-footer for birdie has him at 6-under. Who could blame him for coming back to earth after what happened Friday, right?

    • We’ve already got a 64

      England’s Jordan Smith got out early and showed that there are scores still to be had at Valhalla. Behind six birdies, an eagle and even a bogey, Smith carded an 7-under 6

    • Golf can be cruel

      Brooks Koepka threw a dart into the seventh … and this happened:

      A likely tap in for birdie turned into a par. Koepka is 3-under on his round, but at 7-under for the tournament, a repeat isn’t happening.

    • 13th is driveable

      Here’s something to keep an eye on later in the day: the 349-yard par-4 13th is apparently driveable:

      He’d end up making that short putt for eagle.

      This could get interesting later in the day when the leaders head there with someone needing to make a move.

    • Final round underway

      The final round of the 2024 PGA Championship is underway and, yes, there are scores to be had today. Red figures dot the leaderboard already in the early way, including Brooks Koepka, who’s 2-under on his round through just four holes. If that’s any indication, it’s going to be a shootout to win for those atop the leaderboard.

    Earth-size planet found orbiting nearby star that will outlive the sun by 100 billion years

    0

    Astronomers have discovered an Earth-size planet that is showered with so much radiation, its atmosphere eroded away long ago, leaving it bare. Life as we know it can’t exist on this blistering world, but astronomers are interested in it for another reason: For the first time, they may be able to study the geology of a planet outside our solar system.

    The newfound exoplanet, named SPECULOOS-3 b, is a rocky planet roughly 55 light-years from Earth. It zips around its host star every 17 hours, but days and nights on the planet are endless. Astronomers suspect the planet is tidally locked to its star, like the moon is to Earth. A single dayside always faces the star, while the nightside is locked in eternal darkness. 

    Groundbreaking New Weight Loss Drug Is More Effective Than Current Treatments

    0

    By

    Associate Professor Christoffer Clemmensen from the University of Copenhagen has developed a new type of weight-loss drug that uses the hormone GLP-1 to deliver neuroplasticity-modulating molecules to specific brain areas, significantly enhancing weight loss in mice. This innovative approach could offer a potent alternative to current treatments with fewer side effects and is now moving towards clinical trials.

    A revolutionary study published in Nature introduces a new obesity treatment that surpasses the weight loss results of current drugs in mice. This method involves delivering molecules directly to the brain’s appetite control center, influencing neuroplasticity.

    A new weight-loss drug utilizes the hormone GLP-1 to target brain areas controlling appetite, potentially reducing side effects and improving effectiveness compared to existing drugs, with human trials pending.

    “I consider the drugs available on the marked today as the first generation of weight-loss drugs. Now we have developed a new type of weight-loss drug that affects the plasticity of the brain and appears to be highly effective.”

    So says Associate Professor and Group Leader Christoffer Clemmensen, from the Novo Nordisk Foundation Center for Basic Metabolic Research at the University of Copenhagen, who is senior author of the new study, which has been published in the prestigious scientific journal Nature.

    In the study, Christoffer Clemmensen and colleagues demonstrate a new use of the weight loss hormone GLP-1. GLP-1 can be used as a ‘Trojan Horse’ to smuggle a specific molecule into the brain of mice, where it successfully affects the plasticity of the brain and results in weight loss.

    “The effect of GLP-1 combined with these molecules is very strong. In some cases, the mice lose twice as much weight as mice treated with GLP-1 only,” Christoffer Clemmensen explains.

    This means that future patients can potentially achieve the same effect with a lower dosage. Moreover, the new drug may be an alternative to those who do not respond well to existing weight-loss drugs.

    “Our studies in mice show side effects similar to those experienced by patients treated with the weight loss drugs available on the market today, including nausea. But because the drug is so effective, we may be able to lower the dosage and thus mitigate some of the side effects in the future – though we still don’t know how humans respond to the drug,” he says.

    Testing of the new weight loss drug is still in the so-called preclinical phase, which is based on studies with cells and on experimental animals. The next step is clinical trials with human participants.

    “We already know that GLP-1-based drugs can lead to weight loss. The molecule that we have attached to GLP-1 affects the so-called glutamatergic neurotransmitter system, and in fact, other studies with human participants suggest that this family of compounds has significant weight loss potential. What is interesting here is the effect we get when we combine these two compounds into a single drug,” Christoffer Clemmensen stresses.

    The drug must undergo three phases of clinical trials on human participants. According to Christoffer Clemmensen, it can therefore take eight years before the drug could be available on the market.

    The brain defends excessive body weight

    Christoffer Clemmensen and colleagues developed an interest in molecules that are used to treat chronic depression and Alzheimer’s disease.

    The molecules block a receptor protein called the NMDA receptor, which play a key role in long-term changes in brain connections and have received scientific attention within fields of learning and memory. Drugs targeting these receptors will strengthen and/or weaken specific nerve connections.

    “This family of molecules can have a permanent effect on the brain. Studies have demonstrated that even a relative infrequent treatment can lead to persistent changes to the brain pathologies. We also see molecular signatures of neuroplasticity in our work, but in this case in the context of weight loss,” he explains.

    The human body has evolved to protect a certain body weight and fat mass. From an evolutionary perspective, this has probably been to our advantage, as it means that we have been able to survive periods of food scarcity. Today, food scarcity is not a problem in large parts of the world, where an increasing part of the population suffers from obesity.

    “Today, more than one billion people worldwide have a BMI of 30 or more. This makes it increasingly relevant to develop drugs to aid this disease, and which can help the organism to sustain a lower weight. This topic is something we invest a lot of energy in researching,” says Christoffer Clemmensen.

    A Trojan Horse smuggles small molecule modulators of neuroplasticity into appetite-regulating neurons

    We know that drugs based on the intestinal hormone GLP-1 effectively target the part of the brain that is key to weight loss, namely the appetite control center.

    “What is spectacular – on a cellular level – about this new drug is the fact that it combines GLP-1 and molecules that block the NMDA receptor. It exploits GLP-1 as a Trojan Horse to smuggle these small molecules exclusively into the neurons that affect appetite control. Without GLP-1, the molecules that target the NMDA receptor would affect the entire brain and thus be non-specific,” says Postdoc Jonas Petersen from the Clemmensen Group, who is the first author on the study and the chemist who synthesized the molecules.

    Non-specific drugs are often associated with severe side effects, which have previously been seen in drugs for treating different neurobiological conditions.

    “A lot of brain disorders are difficult to treat, because the drugs need to cross the so-called blood-brain barrier. Whereas large molecules like peptides and proteins generally have difficulties accessing the brain, many small molecules have unlimited access to the entire brain. We have used the GLP-1 peptide’s specific access to the appetite control center in the brain to deliver one of these otherwise non-specific substances to this region only,” Christoffer Clemmensen says and adds:

    “In this study, we have focused on obesity and weight loss, but in fact this is a completely new approach for delivering drugs to specific parts of the brain. So, I hope our research can pave the way for a whole new class of drugs for treating conditions like neurodegenerative diseases or psychiatric disorders.”

    Reference: “GLP-1-directed NMDA receptor antagonism for obesity treatment” by Jonas Petersen, Mette Q. Ludwig, Vaida Juozaityte, Pablo Ranea-Robles, Charlotte Svendsen, Eunsang Hwang, Amalie W. Kristensen, Nicole Fadahunsi, Jens Lund, Alberte W. Breum, Cecilie V. Mathiesen, Luisa Sachs, Roger Moreno-Justicia, Rebecca Rohlfs, James C. Ford, Jonathan D. Douros, Brian Finan, Bryan Portillo, Kyle Grose, Jacob E. Petersen, Mette Trauelsen, Annette Feuchtinger, Richard D. DiMarchi, Thue W. Schwartz, Atul S. Deshmukh, Morten B. Thomsen, Kristi A. Kohlmeier, Kevin W. Williams, Tune H. Pers, Bente Frølund, Kristian Strømgaard, Anders B. Klein and Christoffer Clemmensen, 15 May 2024, Nature.
    DOI: 10.1038/s41586-024-07419-8

    Christoffer Clemmensen, along with postdoc Jonas Petersen and a former scientist from the University of Copenhagen (Anders Klein), have co-founded of the biotech company Ousia Pharma, which is a spinout company from the University of Copenhagen. The company is continuing to develop the medical concept presented in this study for the treatment of severe obesity.

    Blue Origin launch of tourism rocket ends nearly 2-year hiatus

    0

    Blue Origin

    Blue Origin NS-25 launches on Sunday, May 19.

    Sign up for CNN’s Wonder Theory science newsletter. Explore the universe with news on fascinating discoveries, scientific advancements and more.



    CNN
     — 

    Blue Origin’s tourism rocket has launched passengers to the edge of space for the first time in nearly two years, ending a hiatus prompted by a failed uncrewed test flight.

    The New Shepard rocket and capsule lifted off at 9:36 a.m. CT (10:36 a.m. ET) from Blue Origin’s facilities on a private ranch in West Texas. The expected launch time has since shifted to 8:52 a.m. CT (9:52 a.m. ET), according to a Sunday update from Blue Origin. A livestream of the mission, called NS-25, will begin at about 8:12 a.m. CT (9:12 a.m. ET) on the Jeff Bezos-founded company’s website.

    NS-25, Blue Origin’s seventh crewed flight to date, carried six customers aboard the capsule: venture capitalist Mason Angel; Sylvain Chiron, founder of the French craft brewery Brasserie Mont-Blanc; software engineer and entrepreneur Kenneth L. Hess; retired accountant Carol Schaller; aviator Gopi Thotakura; and Ed Dwight, a retired US Air Force captain selected by President John F. Kennedy in 1961 to be the nation’s first Black astronaut candidate.

    Despite completing training at the Aerospace Research Pilot School and receiving an Air Force recommendation, Dwight ultimately didn’t make the NASA Astronaut Corps. He went on to become an entrepreneur and a sculptor; a new National Geographic documentary on Black astronauts, “The Space Race,” highlights Dwight’s pioneering story.

    “I had no intention of being an astronaut. That was the last thing on my bucket list,” Dwight said in the documentary. “But once I was given the challenge, then everything changes.”

    Bob Levey/Getty Images

    Ed Dwight attends a screening of “The Space Race” documentary in January in Houston. At 90, Dwight is heading to space more than 60 years after President John F. Kennedy selected him as the nation’s first Black astronaut candidate.

    Dwight completed that challenge and reached the edge of space at the age of 90, making him the oldest person to venture to such heights, according to a spokesperson from Blue Origin.

    During the mission, the crew soared to more than three times the speed of sound, or more than 2,000 miles per hour. The rocket vaulted the capsule past the Kármán line, an area 62 miles (100 kilometers) above Earth’s surface that is widely recognized as the altitude at which outer space begins — but there’s a lot of gray area.

    And at the peak of the flight, passengers experienced a few minutes of weightlessness and striking views of Earth through the cabin windows.

    The launch followed the success of an uncrewed science mission in December — the New Shepard program’s first flight since the mishap more than a year earlier.

    A New Shepard rocket and spacecraft were set to launch a batch of science instruments on September 12, 2022. But one minute into flight, the rocket endured Max Q — an aerospace term that refers to a moment of maximum stress on a vehicle. It occurs when the rocket is at a relatively low altitude — where the atmosphere is still fairly thick — but the spacecraft is moving at high speeds, creating a moment of intense pressure on the vehicle.

    Around that time, the rocket appeared to emit a massive burst of flames. The New Shepard capsule, which rides atop the rocket, then initiated its launch abort system — firing up a small engine to blast itself safely away from the malfunctioning rocket. That system worked as intended, parachuting the capsule to a safe landing.

    Blue Origin later revealed that the cause of the failure was a problem with the engine nozzle, a large cone that directs the flaming exhaust at the rocket’s bottom. Onboard computers accurately detected the failure and shut the engine down, according to the company.

    Blue Origin

    The NS-25 mission will carry a six-person crew, including (from left) Sylvain Chiron, Kenneth L. Hess, Ed Dwight, Gopi Thotakura, Mason Angel and Carol Schaller.

    No injuries were reported on the ground, and Blue Origin said the science payloads and the capsule could be flown again.

    But the rocket, left without a functioning engine, smashed back into the ground and was destroyed. Typically after New Shepard launches, the rocket booster guides itself back to a safe upright landing so it can be flown again.

    During a December interview with podcaster Lex Fridman, Bezos said the escape system that jettisoned the capsule to safety is the most difficult piece of engineering in the entire rocket — but “it is the reason that I am comfortable letting anyone go on New Shepard.”

    “The (rocket) booster is as safe and reliable as we can make it,” Bezos added. “The power density is so enormous that it is impossible to ever be sure that nothing will go wrong. … So the only way to improve safety is to have an escape system.

    “A tourism vehicle has to be designed in my view … to be as safe as one can make it,” he said. “You can’t make it perfectly safe. It’s impossible.”

    Rocket fix and return to service

    The Federal Aviation Administration, which licenses commercial rocket launches and is charged with ensuring public safety, oversaw an investigation into the failure. The probe revealed that the engine nozzle failed because it experienced higher temperatures than what the company had anticipated.

    To fix the issue, Blue Origin said it implemented “design changes to the combustion chamber” — the area of the engine where fuel explosively mixes with oxidizer — and adjusted “operating parameters,” or the data that the company uses to model safe flights.

    “Additional design changes to the nozzle have improved structural performance under thermal and dynamic loads,” the company said in a March 2023 statement.

    The FAA formally concluded the mishap investigation on September 27, 2023, outlining 21 “corrective actions” Blue Origin needed to implement before returning to flight. The agency did not reveal details on what those actions were, noting the report “contains proprietary data and U.S  Export Control information and is not available for public release.”

    The changes and New Shephard’s successful December flight teed up the company to restart its trips to space for thrill seekers.

    Before the September 2022 failure, New Shepard rockets had flown 22 consecutive successful missions — including six with passengers on board. Bezos flew aboard the rocket in 2021. Other notable space tourists previously carried by the vehicle include “Star Trek” actor William Shatner and “Good Morning America” host Michael Strahan.

    CNN’s Madeline Holcombe contributed to this report.